Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : (-) BI97D6
Catalog No.: PC-61318Not For Human Use, Lab Use Only.
(-) BI97D6 (BI112D1) is a potent, pan-active inhibitor of Bcl-2 family proteins with IC50 of 76, 31, 25, and 122 nM for Bcl-xL, Bcl-2, Mcl-1, and Bfl-1, respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
(-) BI97D6 (BI112D1) is a potent, pan-active inhibitor of Bcl-2 family proteins with IC50 of 76, 31, 25, and 122 nM for Bcl-xL, Bcl-2, Mcl-1, and Bfl-1, respectively.
(-) BI97D6 effectively inhibits cell growth in the PC-3 human prostate cancer and H23 human lung cancer cell lines with EC50 of 0.22 and 0.14 uM, respectively.
(-) BI97D6 effectively induces apoptosis in the BP3 human lymphoma cell lines.
(-) BI97D6 displays in vivo efficacy in a prostate cancer xenograft model in mice.
(-) BI97D6 also overcomes ABT-737 resistance in AML, kills AML leukemia stem/progenitor cells while largely sparing normal hematopoietic stem/progenitor cells.
| M.Wt | 586.596 | |
| Formula | C36H26O8 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Wei J, et al. Front Oncol. 2011 Sep 30;1:28.
2. Pan R, et al. Blood. 2015 Jul 16;126(3):363-72.
3. Wei J, et al. J Med Chem. 2009 Jul 23;52(14):4511-23.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
