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(-) BI97D6

Chemical Structure (-) BI97D6

CAS No.: 1256724-10-3

(-) BI97D6 (BI97D6)

Catalog No.: PC-61318Not For Human Use, Lab Use Only.

(-) BI97D6 (BI112D1) is a potent, pan-active inhibitor of Bcl-2 family proteins with IC50 of 76, 31, 25, and 122 nM for Bcl-xL, Bcl-2, Mcl-1, and Bfl-1, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

(-) BI97D6 (BI112D1) is a potent, pan-active inhibitor of Bcl-2 family proteins with IC50 of 76, 31, 25, and 122 nM for Bcl-xL, Bcl-2, Mcl-1, and Bfl-1, respectively; effectively inhibits cell growth in the PC-3 human prostate cancer and H23 human lung cancer cell lines with EC50 of 0.22 and 0.14  uM, respectively; effectively induces apoptosis in the BP3 human lymphoma cell line; displays in vivo efficacy in a prostate cancer xenograft model in mice; also overcomes ABT-737 resistance in AML, kills AML leukemia stem/progenitor cells while largely sparing normal hematopoietic stem/progenitor cells.

Physicochemical Properties

M.Wt 586.596
Formula C36H26O8
CAS No. 1256724-10-3
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
Shipping
Solubility

Chemical Name

5,5'-dibenzyl-6,6',7,7'-tetrahydroxy-3,3'-dimethyl-[2,2'-binaphthalene]-1,1',4,4'-tetraone

Clinical Information

References

1. Wei J, et al. Front Oncol. 2011 Sep 30;1:28.

2. Pan R, et al. Blood. 2015 Jul 16;126(3):363-72.

3. Wei J, et al. J Med Chem. 2009 Jul 23;52(14):4511-23.

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