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Chemical Structure : 10058-F4
CAS No.: 403811-55-2
Catalog No.: PC-43158Not For Human Use, Lab Use Only.
10058-F4 is a specific c-Myc inhibitor that disrupts the association between the c-Myc and Max, inhibits HL60 cell growth with IC50 of 51 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $98 | In stock | |
| 50 mg | $168 | In stock | |
| 100 mg | $298 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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10058-F4 is a specific c-Myc inhibitor that disrupts the association between the c-Myc and Max, inhibits HL60 cell growth with IC50 of 51 uM.
10058-F4 arrests AML cells at G0/G1 phase, downregulates c-Myc expression and upregulates CDK inhibitors p21 and p27.
10058-F4 induces apoptosis through activation of mitochondrial pathway shown by downregulation of Bcl-2, upregulation of Bax, release of cytoplasmic cytochrome C, and cleavage of caspase 3, 7, and 9.
10058-F4 also induces myeloid differentiation.
| M.Wt | 249.3518 | |
| Formula | C12H11NOS2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 41 mg/mL |
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| Chemical Name/SMILES |
4-Thiazolidinone, 5-[(4-ethylphenyl)methylene]-2-thioxo- |
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1. Huang MJ, et al. Exp Hematol. 2006 Nov;34(11):1480-9.
2. Lin CP, et al. Anticancer Drugs. 2007 Feb;18(2):161-70.
3. Wang H, et al. Mol Cancer Ther. 2007 Sep;6(9):2399-408.
4. Guo J, et al. Cancer Chemother Pharmacol. 2009 Mar;63(4):615-25.
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