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Chemical Structure : 5Z-7-Oxozeaenol
Catalog No.: PC-61198Not For Human Use, Lab Use Only.
A potent, selective TAK1 inhibitor with IC50 of 8 nM, displays >33-fold and >62-fold selectivity over MEKK1 and MEKK4 respectively.
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A potent, selective TAK1 inhibitor with IC50 of 8 nM, displays >33-fold and >62-fold selectivity over MEKK1 and MEKK4 respectively; inhibits IL-1-induced activation of NF-κB (IC50= 83 nM) and JNK/p38, inhibits production of inflammatory mediators, and sensitizes cells to TRAIL- and TNF-α-induced apoptosis in vitro; significantly enhances chemotherapeutic efficacy in vivo.
| M.Wt | 362.37 | |
| Formula | C19H22O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ninomiya-Tsuji J, et al. J Biol Chem. 2003 May 16;278(20):18485-90.
2. Choo MK, et al. Mol Cancer Ther. 2006 Dec;5(12):2970-6.
3. Sogabe Y, et al. Bioorg Med Chem Lett. 2015 Feb 1;25(3):593-6.
4. Fan Y, et al. Apoptosis. 2013 Oct;18(10):1224-34.
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