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Chemical Structure : A-357300
Catalog No.: PC-63318Not For Human Use, Lab Use Only.
A-357300 is a potent, selective, reversible MetAP2 inhibitor with IC50 of 0.12 uM, does not inhibit MetAP1 or leucine aminopeptidases at 10 uM.
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A-357300 is a potent, selective, reversible MetAP2 inhibitor with IC50 of 0.12 uM, does not inhibit MetAP1 or leucine aminopeptidases at 10 uM.
A-357300 suppresses tumor growth preclinically without the toxicities observed with TNP-470, induces cytostasis by cell cycle arrest at the G(1) phase selectively in endothelial cells and in a subset of tumor cells, but not in most primary cells of nonendothelial type.
A-357300 inhibits angiogenesis both in vitro and in vivo and shows potent antitumor efficacy in carcinoma, sarcoma, and neuroblastoma murine models.
| M.Wt | 359.869 | |
| Formula | : C15H22ClN3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang J, et al. Cancer Res. 2003 Nov 15;63(22):7861-9.
2. Sheppard GS, et al. Bioorg Med Chem Lett. 2004 Feb 23;14(4):865-8.
3. Morowitz MJ, et al. Clin Cancer Res. 2005 Apr 1;11(7):2680-5.
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