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Chemical Structure : A-893
Catalog No.: PC-60423Not For Human Use, Lab Use Only.
A-893 (A893) is a potent, selective and cell active lysine methyltransferase SMYD2 inhibitor with IC50 of 2.8 nM.
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A-893 (A893) is a potent, selective and cell active lysine methyltransferase SMYD2 inhibitor with IC50 of 2.8 nM; displays high selectivity against a panel of 31 other methyltransferases (<50% inhibition at 1 uM); reduces p53K370me1 without effects on overall p53 levels in A549 p53 cellular assay, has unexpectedly notable improvement in potency (>80-fold) compared with AZ-505 .
| M.Wt | 577.547 | |
| Formula | C29H38Cl2N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sweis RF, et al. ACS Med Chem Lett. 2015 Apr 29;6(6):695-700.
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