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Chemical Structure : AGI-1067
CAS No.: 216167-82-7
Catalog No.: PC-61236Not For Human Use, Lab Use Only.
AGI-1067 (Succinobucol) is a potent inhibitor of TNF-α-inducible expression of VCAM-1, MCP-1 and E-selectin (IC50=6,10 and 25 uM) with concurrent antioxidant and lipid-modulating properties.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote |
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AGI-1067 (Succinobucol) is a potent inhibitor of TNF-α-inducible expression of VCAM-1, MCP-1 and E-selectin (IC50=6,10 and 25 uM) with concurrent antioxidant and lipid-modulating properties.
AGI-1067 (Succinobucol) inhibits atherosclerosis in LDL receptor-deficient and apolipoprotein E-deficient mice.
AGI-1067 (Succinobucol) also reduces VCAM-1 and MCP-1 mRNA levels in lungs of LPS-stimulated mice.
AGI-1067 (Succinobucol) inhibits atherosclerosis not only via its lipid-lowering effects but also by having direct anti-inflammatory effects on the vessel wall.
| M.Wt | 616.916 | |
| Formula | C35H52O5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(4-((1-((3,5-bis(1,1-Dimethylethyl)-4-hydroxyphenyl)sulfanyl)-1-methylethyl)sulfanyl)-2,6-bis(1,1-dimethylethyl)phenoxy)-4-oxobutanoic acid |
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1. Sundell CL, et al. J Pharmacol Exp Ther. 2003 Jun;305(3):1116-23.
2. Meng CQ, et al. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2545-8.
3. Tardif JC, et al. Circulation. 2003 Feb 4;107(4):552-8.
4. Kunsch C, et al. J Pharmacol Exp Ther. 2004 Mar;308(3):820-9.
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