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Chemical Structure : ALDH1A inhibitor 673A
Catalog No.: PC-36129Not For Human Use, Lab Use Only.
ALDH1A inhibitor 673A (ALDH1Ai 673A) is a potent, selective, pan-ALDH1A inhibitor with IC50 of 246, 230 and 348 nM for ALDH1A1, ALDH1A2 and ALDH1A3, respectively.
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ALDH1A inhibitor 673A (ALDH1Ai 673A) is a potent, selective, pan-ALDH1A inhibitor with IC50 of 246, 230 and 348 nM for ALDH1A1, ALDH1A2 and ALDH1A3, respectively.
ALDH1Ai 673A shows no significant activity against ALDH2 (IC50 14 mM) or numerous other ALDH family members.
ALDH1Ai 673A preferentially kills CD133+ ovarian cancer stem-like cells (CSCs), induces necroptotic CSC death, mediated, in part, by the induction of mitochondrial uncoupling proteins (UCPs) and reduction in oxidative phosphorylation.
ALDH1Ai 673A is highly synergistic with chemotherapy, reducing tumor initiation capacity and increasing tumor eradication in vivo.
| M.Wt | 223.275 | |
| Formula | C15H13NO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chefetz I, et al. Cell Rep. 2019 Mar 12;26(11):3061-3075.e6.
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