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Chemical Structure : ALW-II-49-7
Catalog No.: PC-62396Not For Human Use, Lab Use Only.
ALW-II-49-7 (DDR2-IN-1) is a potent, selective DDR2 inhibitor with IC50 of 18.6 nM, also shows ability to inhibit DDR1 and Ephrin-family kinases (IC50=40 nM for EphB2).
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ALW-II-49-7 (DDR2-IN-1) is a potent, selective DDR2 inhibitor with IC50 of 18.6 nM, also shows ability to inhibit DDR1 and Ephrin-family kinases (IC50=40 nM for EphB2); displays excellent overall kinase selectivity against a panel of over 350 kinases; decreases DDR2 phosphorylation but has little effect on the proliferation of DDR2 mutated cancer cell lines.
| M.Wt | 414.388 | |
| Formula | C21H17F3N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Terai H, et al. ACS Chem Biol. 2015 Dec 18;10(12):2687-96.
2. Choi Y, et al. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4467-70.
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