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Chemical Structure : AMG-176
Catalog No.: PC-70089Not For Human Use, Lab Use Only.
AMG-176 (AMG176) is a novel, potent and selective Mcl-1 inhibitor that binds with high affinity (Ki=0.06 nM) and selectivity to the BH3-binding groove of Mcl-1.
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AMG-176 (AMG176) is a novel, potent and selective Mcl-1 inhibitor that binds with high affinity (Ki=0.06 nM) and selectivity to the BH3-binding groove of Mcl-1.
AMG-176 disrupts the interaction between Mcl-1 and Bak, leading to downstream activation of the intrinsic apoptosis pathway in a cell based split-luciferase complementation assay (IC50=43 nM).
AMG-176 shows robust anti-tumor activity in Mcl-1 dependent cancer models.
AMG-176 is orally bioavailable.
| M.Wt | 613.21 | |
| Formula | C33H41ClN2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sean R. Caenepeel, et al. AACR Annual Meeting 2017; April 1-5, 2017.
2, Caenepeel S, et al. Cancer Discov. 2018 Dec;8(12):1582-1597.
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