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Chemical Structure : AMG 232
CAS No.: 1352066-68-2
Catalog No.: PC-42959Not For Human Use, Lab Use Only.
Navtemadlin (AMG-232) is a potent, selective, orally bioavailable MDM2-p53 inhibitor with Kd of 0.045 nM, inhibits SJSA-1 cell proliferation with IC50 of 9.1 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $498 | In stock | |
| 100 mg | $698 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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Navtemadlin (AMG-232) is a potent, selective, orally bioavailable MDM2-p53 inhibitor with Kd of 0.045 nM, inhibits SJSA-1 cell proliferation with IC50 of 9.1 nM.
Navtemadlin (AMG-232) robustly induces p53 activity, leading to cell-cycle arrest and inhibition of tumor cell proliferation.
Navtemadlin (AMG-232) significantly inhibits tumor growth in SJSA-1 osteosarcoma xenograft model with ED50 of 9.1 mg/kg, also showsignificantly superior antitumor efficacy chombined with chemotherapies in vivo, enhances radiosensitivity via inhibition of damage repair signaling.
| M.Wt | 568.5522 | |
| Formula | C28H35Cl2NO5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-Piperidineacetic acid, 5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(1S)-2-methyl-1-[[(1-methylethyl)sulfonyl]methyl]propyl]-2-oxo-, (3R,5R,6S)- |
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1. Sun D, et al. J Med Chem. 2014 Feb 27;57(4):1454-72.
2. Canon J, et al. Mol Cancer Ther. 2015 Mar;14(3):649-58.
3. Werner LR, et al. Mol Cancer Ther. 2015 Sep;14(9):1994-2003.
4. Prabakaran PJ, et al. Clin Cancer Res. 2017 Oct 15;23(20):6044-6053.
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