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Chemical Structure : AP1903
CAS No.: 195514-63-7
Catalog No.: PC-35967Not For Human Use, Lab Use Only.
AP1903 (Rimiducid, AP-1903) is a potent, specific synthetic ligand of FKBP Phe36Val mutant (F36V-FKBP) with binding IC50 of 1.8 nM.
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|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $228 | In stock | |
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| 100 mg | Get quote |
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AP1903 (Rimiducid, AP-1903) is a potent, specific synthetic ligand of FKBP Phe36Val mutant (F36V-FKBP) with binding IC50 of 1.8 nM.
AP1903 displaces the Fluoresceinated FK506 probe from F36V-FKBP with an IC50 of 5 nM, but shows negligible binding activity to the wild-type protein.
AP1903 elicited potent and dose-dependent apoptotic death of human fibrosarcoma line HT1080 expressing dimerizer-dependent Fas constructs with EC50 of 0.1 nM.
AP1903 induces activation of Fas signaling both in vitro and in vivo, AP1903 is a lipid-permeant dimerizing ligand induced oligomerization and activation of FKBP.
| M.Wt | 1411.65 | |
| Formula | C78H98N4O20 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S,2R,2'R)-(1R,1'R)-((((ethane-1,2-diylbis(azanediyl))bis(2-oxoethane-2,1-diyl))bis(oxy))bis(3,1-phenylene))bis(3-(3,4-dimethoxyphenyl)propane-1,1-diyl) bis(1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate) |
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1. Clackson T, et al. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10437-42.
2. Richard RE, et al. Blood. 2000 Jan 15;95(2):430-6.
3. Thomis DC, et al. Blood. 2001 Mar 1;97(5):1249-57.
4. Narayanan P, et al. J Clin Invest. 2011 Apr;121(4):1524-34.
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