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Chemical Structure : AQX 1125
CAS No.: 782487-28-9
Catalog No.: PC-50004Not For Human Use, Lab Use Only.
AQX 1125 (Rosiptor) is a specific, orally bioavailable SHIP1 activator with no effect on functional androgen, oestrogen, oestrogen-related receptor α, glucocorticoid, mineralocorticoid and progesterone receptor at 30 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $288 | In stock | |
| 10 mg | $458 | In stock | |
| 25 mg | $728 | In stock | |
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| 100 mg | Get quote |
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AQX 1125 (Rosiptor) is a specific, orally bioavailable SHIP1 activator with no effect on functional androgen, oestrogen, oestrogen-related receptor α, glucocorticoid, mineralocorticoid and progesterone receptor at 30 uM.
AQX 1125 (Rosiptor) inhibits the pAkt (S473) in MOLT-4 cells, and inhibits cytokine release in mixed splenocytes.
AQX 1125 (Rosiptor) significantly decreases β-hexosaminidase release in mouse BMMCs.
AQX 1125 (Rosiptor) inhibits chemotaxis in human mononuclear cells (EC50=0.26 uM).
AQX 1125 (Rosiptor) suppresses leukocyte accumulation and inflammatory mediator release in rodent models of pulmonary inflammation and allergy.
| M.Wt | 321.505 | |
| Formula | C20H35NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(1S,3S,4R)-4-((3aS,4R,5S,7aS)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1H-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexan-1-ol |
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1. Stenton GR, et al. Br J Pharmacol. 2013 Mar;168(6):1519-29.
2. Stenton GR, et al. Br J Pharmacol. 2013 Mar;168(6):1506-18.
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