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Chemical Structure : AQX 1125 acetate
Catalog No.: PC-50005Not For Human Use, Lab Use Only.
AQX 1125 acetate (Rosiptor) is a sepecific, orally bioavailable SHIP1 activator with no effect on functional androgen, oestrogen, oestrogen-related receptor α, glucocorticoid, mineralocorticoid and progesterone receptor at 30 uM.
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AQX 1125 acetate (Rosiptor) is a sepecific, orally bioavailable SHIP1 activator with no effect on functional androgen, oestrogen, oestrogen-related receptor α, glucocorticoid, mineralocorticoid and progesterone receptor at 30 uM.
AQX 1125 acetate (Rosiptor) inhibits the pAkt (S473) in MOLT-4 cells, and inhibits cytokine release in mixed splenocytes.
AQX 1125 acetate (Rosiptor) significantly decreases β-hexosaminidase release in mouse BMMCs.
AQX 1125 acetate (Rosiptor) inhibits chemotaxis in human mononuclear cells (EC50=0.26 uM).
AQX 1125 acetate (Rosiptor) suppresses leukocyte accumulation and inflammatory mediator release in rodent models of pulmonary inflammation and allergy.
| M.Wt | 381.557 | |
| Formula | C22H39NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Stenton GR, et al. Br J Pharmacol. 2013 Mar;168(6):1519-29.
2. Stenton GR, et al. Br J Pharmacol. 2013 Mar;168(6):1506-18.
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