Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : AS-605240
CAS No.: 648450-29-7
Catalog No.: PC-42311Not For Human Use, Lab Use Only.
AS-605240 (AS605240) is a potent, selective, ATP-competitive, orally active PI3Kγ inhibitor with IC50 of 8 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $358 | In stock | |
| 500 mg | Get quote | ||
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
AS-605240 (AS605240) is a potent, selective, ATP-competitive, orally active PI3Kγ inhibitor with IC50 of 8 nM.
AS-605240 displays 30-fold selectivity for PI3Kδ、β, 7.5-fold selectivity over PI3Kα.
AS-605240 inhibits C5a-mediated PKB phosphorylation in RAW264 mouse macrophages (IC50=90 nM).
AS-605240 reduces neutrophil chemotaxis in vivo and suppresses joint inflammation and damage in mouse models of RA.
| M.Wt | 257.2679 | |
| Formula | C12H7N3O2S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
DMSO: 5.8 mg/mL (Need warming) |
|
| Chemical Name/SMILES |
2,4-Thiazolidinedione, 5-(6-quinoxalinylmethylene)- |
|
1. Camps M, et al. Nat Med. 2005 Sep;11(9):936-43.
2. Fougerat A, et al. Circulation. 2008 Mar 11;117(10):1310-7.
3. Dutra RC, et al. Br J Pharmacol. 2011 May;163(2):358-74.
4. Kobayashi N, et al. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5753-8.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
