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Chemical Structure : ATN-224
CAS No.: 649749-10-0
Catalog No.: PC-61677Not For Human Use, Lab Use Only.
ATN-224 (Choline tetrathiomolybdate, WTX-101) is a specific, high-affinity copper binder that inhibits CuZn superoxide dismutase 1 (SOD1) with IC50 of 0.33 uM against purified bovine SOD1, leading to antiangiogenic and antitumour effects.
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ATN-224 (Choline tetrathiomolybdate, WTX-101) is a specific, high-affinity copper binder that inhibits CuZn superoxide dismutase 1 (SOD1) with IC50 of 0.33 uM against purified bovine SOD1, leading to antiangiogenic and antitumour effects.
ATN-224 shows no binding to calcium, iron, magnesium, zinc, or manganese ions at 1 mM.
ATN-224 inhibits HUVEC proliferation with IC50 1.4 uM.
ATN-224 shows a potential therapy against Wilson's disease.
| M.Wt | 432.542 | |
| Formula | C10H28MoN2O2S4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-hydroxy-N,N,N-trimethyl-ethanaminium, tetrathioxomolybdate |
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1. Juarez JC, et al. Clin Cancer Res. 2006 Aug 15;12(16):4974-82.
2. Doñate F, et al. Br J Cancer. 2008 Feb 26;98(4):776-83.
3. Calderon-Aparicio A, et al. Oncotarget. 2015 Oct 6;6(30):29771-81.
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