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Chemical Structure : ATR-101
Catalog No.: PC-70112Not For Human Use, Lab Use Only.
ATR-101 (PD-132301, Nevanimibe) is a selective and potent inhibitor of ACAT1 with IC50 of 52 nM.
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ATR-101 (PD-132301, Nevanimibe) is a selective and potent inhibitor of ACAT1 with IC50 of 52 nM; induces H295R cell apoptosis, causes mitochondrial hyperpolarization, reactive oxygen release, and ATP depletion, caspase-3/7 activation, and membrane permeabilization; decreases the formation of cholesteryl esters and increases FC levels in H295R adrenocortical carcinoma cells; inhibits the establishment and impeds the growth of ACC-derived H295R cell xenografts in mice; orally active.
Cushing Disease
Phase 2 Clinical
| M.Wt | 458.09 | |
| Formula | C27H40ClN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. LaPensee CR, et al. Endocrinology. 2016 May;157(5):1775-88.
2. Trivedi BK, et al. J Med Chem. 1994 May 27;37(11):1652-9.
3. Cheng Y, et al. Endocr Relat Cancer. 2016 Apr;23(4):1-19.
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