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AZ 628

Chemical Structure : AZ 628

CAS No.: 878739-06-1

AZ 628 (AZ-628;AZ628)

Catalog No.: PC-42780Not For Human Use, Lab Use Only.

AZ 628(AZ-628, AZ628) is a potent and selective B-Raf inhibitor with IC50s of 2.14 uM and 0.19 uM for wt Braf and Braf V600E respectively..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AZ 628(AZ-628, AZ628) is a potent and selective B-Raf inhibitor with IC50s of 2.14 uM and 0.19 uM for wt Braf and Braf V600E respectively.

Physicochemical Properties

M.Wt 451.5197
Formula C27H25N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Benzamide, 3-(1-cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]-

References

1. McDermott U, et al. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19936-41.

2. Wenglowsky S, et al. Bioorg Med Chem Lett. 2014 Apr 15;24(8):1923-7.

3. Whittaker SR, et al. Cancer Discov. 2013 Mar;3(3):350-62.

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