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Chemical Structure : AZ82
Catalog No.: PC-62374Not For Human Use, Lab Use Only.
AZ82 (KIFC1 inhibitor AZ82) is the first reported small molecule inhibitor of motor protein KIFC1 that inhibits the MT-stimulated KIFC1 enzymatic activity in an ATP-competitive and MT-noncompetitive manner with Ki of 43 nM.
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AZ82 (KIFC1 inhibitor AZ82) is the first reported small molecule inhibitor of motor protein KIFC1 that inhibits the MT-stimulated KIFC1 enzymatic activity in an ATP-competitive and MT-noncompetitive manner with Ki of 43 nM; effectively engages with the minus end-directed KIFC1 motor inside cells to reverse the monopolar spindle phenotype induced by the inhibition of the plus end-directed kinesin Eg5; causes centrosome declustering in BT-549 breast cancer cells with amplified centrosomes.
| M.Wt | 560.6 | |
| Formula | C28H31F3N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wu J, et al. ACS Chem Biol. 2013 Oct 18;8(10):2201-8.
2. Yang B, et al. J Med Chem. 2014 Dec 11;57(23):9958-70.
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