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AZD-0837

Chemical Structure : AZD-0837

CAS No.: 433937-93-0

AZD-0837 (AZD0837;Atecegatran metoxil)

Catalog No.: PC-63163Not For Human Use, Lab Use Only.

AZD-0837 is a novel oral anticoagulant that after bioconversion to its active form is a potent and reversible thrombin inhibitor, has been investigated in phase II studies for prevention of stroke and systemic embolic events in patients with atrial fibrillation (AF)..

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AZD-0837 is a novel oral anticoagulant that after bioconversion to its active form is a potent and reversible thrombin inhibitor, has been investigated in phase II studies for prevention of stroke and systemic embolic events in patients with atrial fibrillation (AF).

Thrombosis

Phase 2 Discontinued

Physicochemical Properties

M.Wt 496.896
Formula C22H23ClF2N4O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-1-((R)-2-(3-chloro-5-(difluoromethoxy)phenyl)-2-hydroxyacetyl)-N-(4-(N-methoxycarbamimidoyl)benzyl)azetidine-2-carboxamide

References

1. Schützer KM, et al. Eur J Clin Pharmacol. 2010 Sep;66(9):903-10.

2. Lip GY, et al. Thromb Res. 2011 Feb;127(2):91-9.

3. Matsson EM, et al. Mol Pharm. 2013 Nov 4;10(11):4252-62.

4. Deinum J, et al. Thromb Haemost. 2009 Jun;101(6):1051-9.

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