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Chemical Structure : AZD-4573
CAS No.: 2057509-72-3
Catalog No.: PC-35250Not For Human Use, Lab Use Only.
AZD-4573 (AZD4573) is a potent and selective inhibitor of CDK9, with fast-off binding kinetics and high selectivity versus other kinases, including other CDK family kinases.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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AZD-4573 (AZD4573) is a potent and selective inhibitor of CDK9 with IC50 of <4 nM, with fast-off binding kinetics and high selectivity versus other kinases, including other CDK family kinases.
AZD4573 exhibits a short half-life in multiple preclinical species and good solubility for intravenous administration.
AZD-4573 dose- and time-dependently decreases cellular pSer2-RNAPII, resulting in activation of caspase 3 and cell apoptosis in a broad range of haematological cancer cell lines.
AZD-4573 demonstrates in vivo efficacyin xenograft models derived from multiple haematological tumours.
| M.Wt | 429.949 | |
| Formula | C22H28ClN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(1S,3R)-3-acetamido-N-(5-chloro-4-(5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)pyridin-2-yl)cyclohexane-1-carboxamide |
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1, Cidado J, et al. Clin Cancer Res. 2019 Nov 7. pii: clincanres.1853.2019.
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