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Chemical Structure : Alendronate sodium hydrate
CAS No.: 121268-17-5
Catalog No.: PC-42809Not For Human Use, Lab Use Only.
Alendronate sodium hydrate (Alendronate.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 100 mg | $48 | In stock | |
| 500 mg | $88 | In stock | |
| 1 g | $138 | In stock | |
| 5 g | Get quote |
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Alendronate sodium hydrate (Alendronate;MK 217;G-704650 Adronat) is a bisphosphonate that acts as a specific inhibitor of osteoclastmediated bone resorption, inhibits osteoclast protein-tyrosine phosphatase (PTPepsilon) with IC50 of 2 uM; also inhibits the activities of other bacterially expressed PTPs such as PTPsigma and CD45, suppresses in vitro formation of multinucleated osteoclasts from osteoclast precursors and in vitro bone resorption by isolated rat osteoclasts with IC50 of 10 uM; also is also inhibits farnesyl disphosphate synthase with IC50 of 1.7 uM.
Osteoporosis
Approved
| M.Wt | 325.1237 | |
| Formula | C4H18NNaO10P2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
H2O: ≥ 28.57 mg/mL; DMSO: < 3.2 mg/mL |
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| Chemical Name/SMILES |
Phosphonic acid, P,P'-(4-amino-1-hydroxybutylidene)bis-, sodium salt, hydrate (1:1:3) |
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1. Bergstrom JD, et al. Arch Biochem Biophys. 2000 Jan 1;373(1):231-41.
2. Opas EE, et al.Biochem Pharmacol. 1997 Sep 15;54(6):721-7.
3. David P, et al. J Bone Miner Res. 1996 Oct;11(10):1498-507.
4. Schmidt A, et al. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3068-73.
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