Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Avitinib
CAS No.: 1557267-42-1
Catalog No.: PC-61449Not For Human Use, Lab Use Only.
Avitinib (Abivertinib, AC-0010, AC0010) is an orally available, irreversible, and mutant-selective EGFR inhibitor with IC50 of 0.18 nM against EGFR L858R/T790M.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $158 | In stock | |
| 50 mg | $278 | In stock | |
| 100 mg | $498 | In stock | |
| 200 mg | $758 | In stock | |
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Avitinib (Abivertinib, AC-0010, AC0010) is an orally available, irreversible, and mutant-selective EGFR inhibitor with IC50 of 0.18 nM against EGFR L858R/T790M.
Avitinib (Abivertinib, AC-0010) displays 43-fold greater potency over wild-type EGFR (IC50=7.68 nM).
Avitinib (Abivertinib, AC-0010) selectively inhibits mutant EGFR phosphorylation (IC50 =7.3 nM and 2.8 nM) in NCI-H1975 and NIH/3T3_TC32T8 cells, 115- and 298-fold more sensitive than that of the inhibition of wild type EGFR in A431.
Avitinib (Abivertinib, AC-0010) overcomes T790M-induced resistance in animal models and lung cancer patients without hyperglycemia or other severe adverse effects.
| M.Wt | 487.539 | |
| Formula | C26H26FN7O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-[3-[[2-[[3-Fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]-2-propenamide |
|
1. Xu X, et al. Mol Cancer Ther. 2016 Nov;15(11):2586-2597.
2. Wang W, et al. J Pharm Biomed Anal. 2017 May 30;139:205-214.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
