Chemical Structure : BAY 60-6583
Catalog No.: PC-35002Not For Human Use, Lab Use Only.
BAY 60-6583 (BAY606583) is a potent, selective adenosine A2B receptor agonist with EC50 of 2.83 nM (murine A2BR).
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BAY 60-6583 (BAY606583) is a potent, selective adenosine A2B receptor agonist with EC50 of 2.83 nM (murine A2BR); inhibits fMLP-stimulated superoxide production by either naive neutrophils,TNF-α-primed neutrophils, or neutrophils isolated from mice at 1-10 nM; increases fMLP-stimulated superoxide production at higher concentrations (>1 uM); exhibits cardioprotective activity, attenuates infarct size in mouse model of myocardial ischemia.
M.Wt | 379.438 | |
Formula | C19H17N5O2S | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
1. van der Hoeven D, et al. J Pharmacol Exp Ther. 2011 Sep;338(3):1004-12.
2. Eckle T, et al. Circulation. 2007 Mar 27;115(12):1581-90.
3. Teng B, et al. J Mol Cell Cardiol. 2008 May;44(5):905-14.
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