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Chemical Structure : BC-1215
CAS No.: 1507370-20-8
Catalog No.: PC-60879Not For Human Use, Lab Use Only.
BC-1215 (BC1215) is a highly unique, selective E3 ligase F box component Fbxo3 inhibitor with IL1β IC50 of 0.9 ug/mL.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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BC-1215 (BC1215) is a potent, highly unique, selective E3 ligase F box component Fbxo3 inhibitor with IL1β IC50 of 0.9 ug/mL.
BC-1215 inhibits the Fbxo3-TRAF activation pathway for cytokine release, increases immunoreactive Fbxl2 levels and reduces TRAF proteins, impairs Fbxo3 ubiquitination of Fbxl2 with IC50 of 0.1 uM in vitro ubiquitination assay.
BC-1215 reversibly inhibits Fbxo3 to destabilize TRAF proteins, remarkably suppresses the majority of the Th1 panel cytokines including G-CSF, GM-CSF, GROα, I-309, IL1-α, IL1-β, IL1rα, IL-6, IL-12, IL-23, MIP-1α, MIP-1β and TNFα, in PBMCs.
BC-1215 ameliorates the severity of viral pneumonia, septic shock, colitis, and cytokine-driven inflammation systemically in murine models.
| M.Wt | 394.522 | |
| Formula | C26H26N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N1,N2-bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine |
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1. Mallampalli RK, et al. J Immunol. 2013 Nov 15;191(10):5247-55.
2. Lin TB, et al. J Neurosci. 2015 Dec 16;35(50):16545-60.
3. Lai CY, et al. J Neurosci. 2016 Sep 14;36(37):9722-38.
4. Chen BB, et al. Nat Immunol. 2013 May;14(5):470-9.
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