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BCX4430 freebase

Chemical Structure : BCX4430 freebase

CAS No.: 249503-25-1

BCX4430 freebase (Galidesivir)

Catalog No.: PC-45503Not For Human Use, Lab Use Only.

A viral RNA-dependent RNA polymerase (RdRp) inhibitor that acts as a non-obligate RNA chain terminator.

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Biological Activity

A viral RNA-dependent RNA polymerase (RdRp) inhibitor that acts as a non-obligate RNA chain terminator; exhibits broad-spectrum antiviral activity against negative-sense RNA viruses representing the Filoviridae, Arenaviridae, Bunyaviridae,Orthomyxoviridae,Picornaviridae and Paramyxoviridae families, and positive-sense RNA viruses of the Flaviviridae and Coronaviridae families (EC50=5-60 uM).

Ebola Virus Infection

Phase 1 Clinical

Physicochemical Properties

M.Wt 265.2685
Formula C11H15N5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

H2O: 1.53 mg/mL (Need ultrasonic and warming)

Chemical Name/SMILES

3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-, (2S,3S,4R,5R)-

References

1. Warren TK, et al. Nature. 2014 Apr 17;508(7496):402-5.

2. Julander JG, et al. Antimicrob Agents Chemother. 2014 Nov;58(11):6607-14.

3. Julander JG, et al. Antiviral Res. 2017 Jan;137:14-22.

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