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Chemical Structure : BF738735
Catalog No.: PC-63341Not For Human Use, Lab Use Only.
BF738735 is a novel, broad-spectrum inhibitor of enterovirus replication (EC50=4-71 nM) that specifically targets host cell factor PI4KIIIβ with IC50 of 5.7 nM, 300-fold less potent for PI4KIIIα (IC50=1.7 uM).
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BF738735 is a novel, broad-spectrum inhibitor of enterovirus replication (EC50=4-71 nM) that specifically targets host cell factor PI4KIIIβ with IC50 of 5.7 nM, 300-fold less potent for PI4KIIIα (IC50=1.7 uM); blocks viral RNA replication with IC50 of 77 nM in luciferase assays, strongly inhibits CVB3 and EV71 replicon replication at 1-5 uM; reduces the PI4P levels at the Golgi complex through a direct inhibition of PI4KIIIβ activity.
| M.Wt | 426.466 | |
| Formula | C21H19FN4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. MacLeod AM, et al. ACS Med Chem Lett. 2013 May 8;4(7):585-9.
2. Melia CE, et al. Cell Rep. 2017 Oct 17;21(3):587-599.
3. van der Schaar HM, et al. Antimicrob Agents Chemother. 2013 Oct;57(10):4971-81.
4. Ulferts R, et al. Antimicrob Agents Chemother. 2016 Apr 22;60(5):2627-38.
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