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Chemical Structure : BI 135585
Catalog No.: PC-60448Not For Human Use, Lab Use Only.
BI 135585 (BI-135585, BI135585) is a potent, selective, orally active 11β-HSD1 inhibitor with IC50 of 4.3 nM and 53 nM in human adipocytes and primary human adipose tissue, respectively.
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BI 135585 (BI-135585, BI135585) is a potent, selective, orally active 11β-HSD1 inhibitor with IC50 of 4.3 nM and 53 nM in human adipocytes and primary human adipose tissue, respectively.
BI 135585 exhibits >1,000-fold selectivity over other hydroxysteroid dehydrogenases.
BI 135585 inhibits 11β HSD1 activity in adipose tissue, displays desirable pharmacodynamic properties in vivo.
| M.Wt | 460.574 | |
| Formula | C28H32N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hamilton BS, et al. Eur J Pharmacol. 2015 Jan 5;746:50-5.
2. Freude S, et al. Diabetes Obes Metab. 2016 May;18(5):483-90.
3. Zhuang L, et al. Bioorg Med Chem. 2017 Jul 15;25(14):3649-3657.
4. Hamilton BS, et al. Eur J Pharmacol. 2016 Oct 15;789:68-74.
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