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Chemical Structure : BI8622
CAS No.: 1875036-74-0
Catalog No.: PC-63514Not For Human Use, Lab Use Only.
BI8622 (BI-8622) is a specific small molecule inhibitor of the HUWE1 ubiquitin ligase with IC50 of 3.1 uM, does not inhibit the activity of other HECT-domain ubiquitin ligases (HECW2, NEDD4,UBA1 and UbcH5b).
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|---|---|---|---|
| 5 mg | $298 | In stock | |
| 10 mg | $488 | In stock | |
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| 50 mg | Get quote | ||
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BI8622 (BI-8622) is a specific small molecule inhibitor of the HUWE1 ubiquitin ligase with IC50 of 3.1 uM, does not inhibit the activity of other HECT-domain ubiquitin ligases (HECW2, NEDD4,UBA1 and UbcH5b).
BI8622 abolishes ubiquitination of MCL1 induced by ectopically expressed HUWE1 in HeLa cells with IC50 of 6.8 uM, suppresses colony formation of Ls174T cells with IC50 of 8.4 uM.
BI8622 inhibits MYC-dependent transactivation in colorectal cancer cells, but not in stem and normal colon epithelial cells.
BI8622 stabilizes MYC-associated protein MIZ1.
| M.Wt | 426.524 | |
| Formula | C25H26N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(4-(aminomethyl)phenyl)-6-(4-cyano-4-phenylpiperidin-1-yl)-5-methylpyrimidine-4-carboxamide |
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1. Peter S, et al. EMBO Mol Med. 2014 Dec;6(12):1525-41.
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