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BMS-394136

Chemical Structure : BMS-394136

CAS No.: 343246-73-1

BMS-394136 (BMS394136)

Catalog No.: PC-63569Not For Human Use, Lab Use Only.

BMS-394136 is a potent, selective IKur/Kv1.5inhibitor, increases atrial action potential duration (APD) and prolongs AERP but not VERP in both rabbits and beagles..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BMS-394136 is a potent, selective IKur/Kv1.5 inhibitor, increases atrial action potential duration (APD) and prolongs AERP but not VERP in both rabbits and beagles.

    Physicochemical Properties

    M.Wt 471.357
    Formula C24H21Cl2FN4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    Pyrrolidine, 1-[[(7R)-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-fluorophenyl)-, (2S)- (9CI)

    References

    1. Dezhi Xing, et al. Abstract 2515: A Selective IKur Blocker, BMS-394136 Selectively Prolongs Atrial APD and Refractoriness in Beagles and Rabbits. Circulation. 2009;120:S654.

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