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Chemical Structure : BMS-955176
Catalog No.: PC-61452Not For Human Use, Lab Use Only.
BMS-955176 (GSK-3532795) is a second-generation HIV-1 maturation inhibitor that exhibits potent activity (EC50=3.9±3.4 nM) against a library (n=87) of gag/pr recombinant viruses.
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BMS-955176 (GSK-3532795) is a second-generation HIV-1 maturation inhibitor that exhibits potent activity (EC50=3.9±3.4 nM) against a library (n=87) of gag/pr recombinant viruses; exhibits median EC50 of 21 nM toward a library of subtype B clinical isolates assayed in PBMCs; inhibits HIV-1 protease cleavage at the CA/SP1 junction within Gag in VLPs and in HIV-1-infected cells, and binds reversibly and with high affinity to assembled Gag in purified HIV-1 VLPs; has a greatly improved preclinical profile compared to that of Bevirimat.
HIV Infection
Phase 2 Clinical
| M.Wt | 691.03 | |
| Formula | C42H62N2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nowicka-Sans B, et al. Antimicrob Agents Chemother. 2016 Jun 20;60(7):3956-69.
2. Regueiro-Ren A, et al. ACS Med Chem Lett. 2016 Apr 22;7(6):568-72.
3. Lin Z, et al. PLoS Pathog. 2016 Nov 28;12(11):e1005990.
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