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Chemical Structure : BTX161
CAS No.: 2052301-24-1
Catalog No.: PC-35629Not For Human Use, Lab Use Only.
BTX161 is a thalidomide analog that mediates degradation of CKIα better than lenalidomide in human AML cells and activates DDR and p53, while stabilizing the p53 antagonist MDM2.
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BTX161 is a thalidomide analog that mediates degradation of CKIα better than lenalidomide in human AML cells and activates DDR and p53, while stabilizing the p53 antagonist MDM2.
BTX161 upregulates all the Wnt targets including MYC and does not affect MDM2 mRNA expression.
| M.Wt | 272.304 | |
| Formula | C15H16N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-3-(4-methyl-1-oxoisoindolin-2-yl)azepane-2,7-dione |
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1. Minzel W, et al. Cell. 2018 Aug 20. pii: S0092-8674(18)30973-5. doi: 10.1016/j.cell.2018.07.045.
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