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Besifovir

Chemical Structure : Besifovir

CAS No.: 441785-26-8

Besifovir (PMCDG Dipivoxil;ANA-380;LB-80380)

Catalog No.: PC-63285Not For Human Use, Lab Use Only.

Besifovir (PMCDG Dipivoxil, NA-380, LB-80380) is a potent, selective, orally available anti-HBV agent, the prodrug of PMCDG (EC50=4 uM)..

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Besifovir (PMCDG Dipivoxil, NA-380, LB-80380) is a potent, selective, orally available anti-HBV agent, the prodrug of PMCDG (EC50=4 uM).

HBV Infection

Phase 3 Clinical

Physicochemical Properties

M.Wt 527.515
Formula C22H34N5O8P
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

[[1-[(2-aminopurin-9-yl)methyl]cyclopropyl]oxymethyl-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate

References

1. Choi JR, et al. J Med Chem. 2004 May 20;47(11):2864-9.

2. Yuen MF, et al. Hepatology. 2010 Mar;51(3):767-76.

3. Papatheodoridis GV, et al. Curr Opin Mol Ther. 2006 Aug;8(4):352-7.

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