Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : CH223191
Catalog No.: PC-60778Not For Human Use, Lab Use Only.
A potent, specific aryl hydrocarbon receptor (AhR) antagonist that potently inhibits TCDD-induced AhR-dependent transcription with IC50 of 0.03 uM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
A potent, specific aryl hydrocarbon receptor (AhR) antagonist that potently inhibits TCDD-induced AhR-dependent transcription with IC50 of 0.03 uM; shows no agonist-like effect, and no activity on estrogen receptor; inhibits TCDD-AhR binding and TCDD-induced nuclear translocation and DNA binding of AhR, blocks TCDD-mediated cytochrome P450 expression (CYP1A1) in HepG2 cells; prevents TCDD-elicited cytochrome P450 induction, liver toxicity, and wasting syndrome in mice.
| M.Wt | 333.395 | |
| Formula | C19H19N5O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Kim SH, et al. Mol Pharmacol. 2006 Jun;69(6):1871-8.
2. Veldhoen M, et al. J Exp Med. 2009 Jan 16;206(1):43-9.
3. Choi EY, et al. Mol Pharmacol. 2012 Jan;81(1):3-11.
4. Ramirez JM, et al. Eur J Immunol. 2010 Sep;40(9):2450-9.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
