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Chemical Structure : CHIR-98014
CAS No.: 252935-94-7
Catalog No.: PC-43377Not For Human Use, Lab Use Only.
CHIR-98014 is a potent, selective glycogen synthase kinase 3 (GSK-3) withIC50 of 0.65 and 0.58 nM for GSK-3α and GSK-3β, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 25 mg | $298 | In stock | |
| 100 mg | $588 | In stock | |
| 500 mg | Get quote |
Bulk size, bulk discount!
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CHIR-98014 is a potent, selective glycogen synthase kinase 3 (GSK-3) withIC50 of 0.65 and 0.58 nM for GSK-3α and GSK-3β, respectively; shows less potent activities against 20 other protein kinases including Cdc2 and Erk2; causes GS stimulation in CHO-IR cells and rat hepatocytes, with EC50s of 106 nM and 107 nM, respectively; reduces the viability of ES-CCE cells with IC50 of 1.1 uM, results in a significant activation of the Wnt/beta-catenin pathway in ES-D3 cells combined with CHIR-99021; significantly reduces fasting hyperglycemia within and shows improved glucose disposal in diabetic and insulin-resistant db/db mice.
| M.Wt | 486.3141 | |
| Formula | C20H17Cl2N9O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 11 mg/mL |
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| Chemical Name/SMILES |
2,6-Pyridinediamine, N6-[2-[[4-(2,4-dichlorophenyl)-5-(1H-imidazol-1-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro- |
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1. Ring DB, et al. Diabetes. 2003 Mar;52(3):588-95.
2. Lian X, et al. Cell Reports. 2015 Jan 13;4(1):170.
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