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Chemical Structure : CK-101
CAS No.: 1660963-42-7
Catalog No.: PC-61597Not For Human Use, Lab Use Only.
CK-101 (Olafertinib, RX-518) is a novel potent, mutant-selective, irreversible, orally available EGFR inhibitor, overcomes T790M-mediated resistance in NSCLC.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $228 | In stock | |
| 25 mg | $428 | In stock | |
| 50 mg | $728 | In stock | |
| 100 mg | $1280 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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CK-101 (Olafertinib, RX-518) is a novel potent, mutant-selective, irreversible, orally available EGFR inhibitor, overcomes T790M-mediated resistance in NSCLC.
CK-101 (Olafertinib, RX-518) specifically targets the mutant forms of EGFR, including T790M, while exhibiting minimal activity toward WT EGFR.
CK-101 (Olafertinib, RX-518) selectively inhibits cell proliferation of cell lines expressing both the activating (HCC827, IC50 <15 nM) and resistance mutations (NCI-H1975, IC50 <5 nM).
CK-101 (Olafertinib, RX-518) significantly inhibits tumor growth in EGFR-mutated NSCLC tumor xenograft models, with no activity in WT EGFR tumor xenograft model.
| M.Wt | 530.58 | |
| Formula | C29H28F2N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[3-[2-[2,3-difluoro-4-[4-(2-hydroxyethyl)piperazin-1-yl]anilino]quinazolin-8-yl]phenyl]prop-2-enamide |
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1. Xiangping Qian, et al. Abstract 2078: CK-101 (RX518), a mutant-selective inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC. DOI: 10.1158/1538-7445.AM2017-2078
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