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Chemical Structure : CLK2 inhibitor Indazole 1
Catalog No.: PC-35359Not For Human Use, Lab Use Only.
CLK2 inhibitor Indazole1 is a novel potent, selective inhibitor of CLK2 with IC50 of 2.7 nM, 60-fold selectivity over PKA and >600-fold selectivity over a panel of 34 kinases.
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CLK2 inhibitor Indazole1 is a novel potent, selective inhibitor of CLK2 with IC50 of 2.7 nM, 60-fold selectivity over PKA and >600-fold selectivity over a panel of 34 kinases.
CLK2 inhibitor Indazole1 rescues spine density in mouse brain slices at 300 nM.
CLK2 inhibitor Indazole1 displays 96-fold more potent than TG003 in the CLK2 Caliper assay.
| M.Wt | 324.428 | |
| Formula | C19H24N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lerchner AM, et al. ChemMedChem. 2018 Jul 9. doi: 10.1002/cmdc.201800344.
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