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CRANAD 2

Chemical Structure : CRANAD 2

CAS No.: 1193447-34-5

CRANAD 2

Catalog No.: PC-38441Not For Human Use, Lab Use Only.

CRANAD 2 is a blood-brain barrier penetrant, near-infrared probe that binds to Aβ40 aggregates (Kd = 38 nM) and elicits an emission blue shift, for the detection of amyloid-β (Aβ) deposits in vitro and in vivo.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CRANAD 2 is a blood-brain barrier penetrant, near-infrared probe that binds to Aβ40 aggregates (Kd = 38 nM) and elicits an emission blue shift, for the detection of amyloid-β (Aβ) deposits in vitro and in vivo.
CRANAD 2 directly binds to amyloid-β (Aβ) plaques in vitro and APP-PS1 transgenic mice.
CRANAD 2 exhibits a 70-fold increase in fluorescence intensity, a blue shift from 805 to 715 nm, and a large increase in quantum yield.

Physicochemical Properties

M.Wt 410.3
Formula C23H25BF2N2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

References

1. Chongzhao Ran, et al. J Am Chem Soc. 2009 Oct 28;131(42):15257-61.

2. Chongzhao Ran, et al. PLoS One. 2011 Apr 29;6(4):e19362.

3. Torra J, et al. Chemistry. 2022 Apr 1;28(19):e202200026.

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