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Chemical Structure : CS-526
Catalog No.: PC-62893Not For Human Use, Lab Use Only.
CS-526 (AKU 517.
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CS-526 (AKU 517;R 105266) is a potent, competitive, and reversible acid pump antagonist (potassium-competitive acid blocker) that inhibits H+,K+-ATPase activity with IC50 of 61 nM; inhibits gastric acid secretion in pylorus-ligated rats with ID50 of 0.7 mg/kg (p.o.); inhibits histamine-stimulated gastric acid secretion in Heidenhain pouch dogs, inhibits acute gastric mucosal lesions and has potent antisecretory and antiulcer effects.
Ulcer
Phase 1 Discontinued
| M.Wt | 339.414 | |
| Formula | C20H22FN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ito K, et al. J Pharmacol Exp Ther. 2007 Oct;323(1):308-17.
2. Ito K, et al. J Pharmacol Exp Ther. 2008 Jul;326(1):163-70.
4. Ito K, et al. Biol Pharm Bull. 2009 Dec;32(12):2010-7.
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