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Chemical Structure : Cariporide
CAS No.: 159138-80-4
Catalog No.: PC-35052Not For Human Use, Lab Use Only.
Cariporide (HOE642) is a potent, selective sodium-hydrogen exchange subtype 1 (NHE1) inhibitor with IC50 of 50 nM, shows little to no activity against NHE3 and NHE2 (IC50=3 and 10 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | $428 | In stock | |
| 250 mg | $728 | In stock | |
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Cariporide (HOE642) is a potent, selective sodium-hydrogen exchange subtype 1 (NHE1) inhibitor with IC50 of 50 nM, shows little to no activity against NHE3 and NHE2 (IC50=3 and 10 uM).
Cariporide (HOE642) inhibits the amiloride sensitive sodium influx in rabbit erythrocytes, reduces the swelling of human platelets induced by intracellular acidification, and delays pH recovery in rat cardiomyocytes.
Cariporide (HOE642) reduces and prevents ventricular premature beats, ventricular tachycardia, and ventricular fibrillation after oral treatment in vivo.
Cariporide (HOE642) shows cardioprotective and antiarrhythmic effects in ischaemic and reperfused hearts.
| M.Wt | 283.346 | |
| Formula | C12H17N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)benzamide |
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1. Scholz W, et al. Cardiovasc Res. 1995 Feb;29(2):260-8.
2. Russ U, et al. Pflugers Arch. 1996 Nov-Dec;433(1-2):26-34.
3. Xue YX, et al. Eur J Pharmacol. 1996 Dec 19;317(2-3):309-16.
4. Aye NN, et al. Eur J Pharmacol. 1997 Nov 27;339(2-3):121-7.
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