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Chemical Structure : Chemocoxib A
Catalog No.: PC-62881Not For Human Use, Lab Use Only.
Chemocoxib A is a highly potent, selective, cytotoxic COX-2 inhibitor with IC50 of 290 nM and 90 nM for wt mCOX-2 and R120Q COX-2 mutant respectively.
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Chemocoxib A is a highly potent, selective, cytotoxic COX-2 inhibitor with IC50 of 290 nM and 90 nM for wt mCOX-2 and R120Q COX-2 mutant respectively; shows no signigicant activity against COX-1, and COX-2 mutant V349L, V523I, and S530A; exhibits cytotoxicity in cancer cell culture, inhibits the growth of human tumor xenografts in nude mice.
| M.Wt | 924.397 | |
| Formula | C49H50ClN3O13 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Uddin MJ, et al. ACS Chem Biol. 2016 Nov 18;11(11):3052-3060.
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