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Chemical Structure : Cipargamin
Catalog No.: PC-63378Not For Human Use, Lab Use Only.
Cipargamin (KAE609, NITD609) is a fast-acting, potent antimalarial agent that inhibits blood-stage activity in vitro against a panel of culture-adapted P. falciparum strains with IC50 of 0.5-1.4 nM.
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Cipargamin (KAE609, NITD609) is a fast-acting, potent antimalarial agent that inhibits blood-stage activity in vitro against a panel of culture-adapted P. falciparum strains with IC50 of 0.5-1.4 nM.
NITD609 inhibits the early and late development of Plasmodium falciparum gametocytes in vitro in a dose-dependent fashion over a range of 5 to 500 nM.
NITD609 also is a very effective drug in reducing transmission to the Anopheles stephensi mosquito vector; shows pharmacokinetic properties compatible with once-daily oral dosing and has single-dose efficacy in rodent malaria model.
| M.Wt | 390.239 | |
| Formula | C19H14Cl2FN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rottmann M, et al. Science. 2010 Sep 3;329(5996):1175-80.
2. van Pelt-Koops JC, et al. Antimicrob Agents Chemother. 2012 Jul;56(7):3544-8.
3. Spillman NJ, et al. Cell Host Microbe. 2013 Feb 13;13(2):227-37.
4. Zhou Y, et al. Antimicrob Agents Chemother. 2014;58(3):1789-92.
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