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Chemical Structure : Compound K
CAS No.: 2320462-65-3
Catalog No.: PC-72055Not For Human Use, Lab Use Only.
Compound K (HPK1 inhibitor CompK) is a novel, potent, highly selective HPK1 (MAP4K1) kinase inhibitor with IC50 of 2.6 nM, 50-fold selectivity against other members of the MAP4K family.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $588 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Compound K (HPK1 inhibitor CompK) is a novel, potent, highly selective HPK1 (MAP4K1) kinase inhibitor with IC50 of 2.6 nM, 50-fold selectivity against other members of the MAP4K family.
Compound K enhanced IFN-γ production in human CD8+ T cells with EC50 of 137 nM, showed potential benefit in restoring T-cell polyfunctionality under immunosuppressive conditions relevant to the TME.
CompK treatment demonstrated markedly enhanced human T-cell immune responses under immunosuppressive conditions relevant to the TME and an increased avidity of the T-cell receptor (TCR) to recognize viral and tumor-associated antigens (TAAs) in significant synergy with anti-PD1.
Animal model studies, revealed improved immune responses and superb antitumor efficacy in combination of CompK with anti-PD-1.
| M.Wt | 458.478 | |
| Formula | C24H22N6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1(3H)-Isobenzofuranone, 5-[[4-[[(1S)-2-hydroxy-1-phenylethyl]amino]-5-(1,3,4-oxadiazol-2-yl)-2-pyrimidinyl]amino]-3,3-dimethyl- |
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1. Dan You, et al. J Immunother Cancer. 2021 Jan;9(1):e001402.
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