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Chemical Structure : Crizotinib
CAS No.: 877399-52-5
Catalog No.: PC-45885Not For Human Use, Lab Use Only.
Crizotinib (PF-02341066;PF-2341066) is a potent, selective, orally bioavailable, ATP-competitive inhibitor of c-Met catalytic activity with Ki of 4 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $80 | In stock | |
| 100 mg | $112 | In stock | |
| 200 mg | $192 | In stock | |
| 500 mg | Get quote | ||
| 1 g | Get quote |
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Crizotinib (PF-02341066, PF-2341066) is a potent, selective, orally bioavailable, ATP-competitive inhibitor of c-Met catalytic activity with Ki of 4 nM.
Crizotinib (PF-02341066) displays >1,000-fold selective for the VEGFR2 and PDGFRβ RTKs, >250-fold selective for IRK and Lck, and ∼40- to 60-fold selective for Tie2, TrkA, and TrkB.
Crizotinib (PF-02341066) also inhibits ALK (IC50=24 nM), potently inhibits c-Met phosphorylation and c-Met-dependent proliferation, migration, or invasion of human tumor cells in vitro (IC50=5-20 nM).
Crizotinib (PF-02341066) shows antitumor efficacy in tumor models at well-tolerated doses in vivo.
| M.Wt | 450.3367 | |
| Formula | C21H22Cl2FN5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 55 mg/mL (Need ultrasonic) |
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| Chemical Name/SMILES |
2-Pyridinamine, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- |
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1. Zou HY, et al. Cancer Res. 2007 May 1;67(9):4408-17.
2. Christensen JG, et al. Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3314-22.
3. Knowles LM, et al. Clin Cancer Res. 2009 Jun 1;15(11):3740-50.
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