Chemical Structure : D4476
CAS No.: 301836-43-1
Catalog No.: PC-42523Not For Human Use, Lab Use Only.
D4476 (Casein Kinase I Inhibitor, D 4476, D-4476) is a potent, selective ATP-competitive inhibitor of CK1 with IC50 of 0.3 uM in vitro.
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D4476 (Casein Kinase I Inhibitor, D 4476, D-4476) is a potent, selective ATP-competitive inhibitor of CK1 with IC50 of 0.3 uM in vitro; slightly weaker for ALK5 inhibition (IC50=0.5 uM); weak activity for p38α MAPK and no activity for PKB, SGK; specifically inhibits the phosphorylation of endogenous FOXO1a on Ser322 and Ser325; more potent and specific than IC261 or CKI-7.
M.Wt | 398.414 | |
Formula | C23H18N4O3 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
Benzamide, 4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]- |
1. Rena G, et al. EMBO Rep. 2004 Jan;5(1):60-5.
2. Bryja V, et al. Cell Signal. 2007 Mar;19(3):610-6.
3. Huart AS, et al. J Biol Chem. 2009 Nov 20;284(47):32384-94.
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