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DS-1040

Chemical Structure : DS-1040

CAS No.: 1335138-62-9

DS-1040 (DS 1040;DS1040)

Catalog No.: PC-61009Not For Human Use, Lab Use Only.

DS-1040 (DS1040) is a small molecule inhibitor of the activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC50 of 1.7 ng/mL for rabbit TAFIa.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DS-1040 (DS1040) is a small molecule inhibitor of the activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC50 of 1.7 ng/mL for rabbit TAFIa; a novel fibrinolysis-enhancing agent has favorable pharmacokinetic/pharmacodynamic properties and a favorable safety profile

    Stroke

    Phase 2 Clinical

    Physicochemical Properties

    M.Wt 293.411
    Formula C16H27N3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (2S)-5-Amino-2-[[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl]valeric acid

    References

    1. Zhou J, et al. J Thromb Haemost. 2017 May;15(5):961-971.

    2. Gurewich V, et al. J Thromb Haemost. 2017 Oct;15(10):2080-2081.

    3. Paul A Lapchak, et al. Abstract WP282: DS-1040 an Inhibitor of the Activated Thrombin Activatable Fibrinolysis Inhibitor Improves Behavior in Embolized Rabbits, Stroke. 2016;47:AWP282.

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