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Chemical Structure : Deleobuvir
Catalog No.: PC-60952Not For Human Use, Lab Use Only.
Deleobuvir (BI-207127, BI207127) is a potent, selective HCV NS5B polymerase inhibitor with IC50 of 50 nM against GT-1 HCV polymerase activity.
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Deleobuvir (BI-207127, BI207127) is a potent, selective HCV NS5B polymerase inhibitor with IC50 of 50 nM against GT-1 HCV polymerase activity; demonstrates subgenomic antiviral activity against GT1b and GT1a with EC50 of 11 and 23 nM in cell-based replicon assays; shows weak or no inhibition in specificity assays that include poliovirus RdRp, mammalian DdRp II, and DNA polymerase α, β, and γ; displays good antiviral potency and tolerability in early clinical trials of short-term treatment either as a single agent or in combination with pegylated IFN-α2a/ribavirin in HCV GT1 patients.
HCV Infection
Phase 3 Clinical
| M.Wt | 653.581 | |
| Formula | C34H33BrN6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zeuzem S, et al. Gastroenterology. 2011 Dec;141(6):2047-55; quiz e14.
2. Zeuzem S, et al. Antivir Ther. 2013;18(8):1015-9.
3. Larrey D, et al. Antimicrob Agents Chemother. 2013 Oct;57(10):4727-35.
4. LaPlante SR, et al. J Med Chem. 2014 Mar 13;57(5):1845-54.
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