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Chemical Structure : Dolutegravir
CAS No.: 1051375-16-6
Catalog No.: PC-43417Not For Human Use, Lab Use Only.
Dolutegravir (GSK1349572) is a potent, next-generation HIV integrase (IN) inhibitor, inhibits HIV-1 integrase-catalyzed strand transfer with IC50 of 2.7 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 25 mg | $278 | In stock | |
| 100 mg | $748 | In stock | |
| 500 mg | Get quote |
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Dolutegravir (GSK1349572) is a potent, next-generation HIV integrase (IN) inhibitor, inhibits HIV-1 integrase-catalyzed strand transfer with IC50 of 2.7 nM; inhibits HIV-1 replication in PBMCs, MT-4 cells and in the PHIV assay with EC50 of 0.51, 0.71 and 2.2 nM, respectively; demonstrates activity against site-directed molecular clones containing the raltegravir-resistant signature mutations Y143R, Q148K, N155H, and G140S/Q148H; exhibits excellent anti-HIV activity in combination with representative approved antiretroviral agents in vivo.
HIV Infection
Approved
| M.Wt | 419.3788 | |
| Formula | C20H19F2N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 10 mg/mL |
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| Chemical Name/SMILES |
2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)- |
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1. Kobayashi M, et al. Antimicrob Agents Chemother. 2011 Feb;55(2):813-21.
2. Garrido C, et al. Antiviral Res. 2011 Jun;90(3):164-7.
3. Hightower KE, et al. Antimicrob Agents Chemother. 2011 Oct;55(10):4552-9.
4. Hare S, et al. Mol Pharmacol. 2011 Oct;80(4):565-72.
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