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Chemical Structure : EOAI3402143
CAS No.: 1699750-95-2
Catalog No.: PC-61303Not For Human Use, Lab Use Only.
EOAI3402143 (Deubiquitinase inhibitor G9, EOAI 3402143) is a novel covalent deubiquitinase Usp9x/Usp24 inhibitor (IC50=1.6 uM).
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|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
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EOAI3402143 (Deubiquitinase inhibitor G9, EOAI 3402143) is a novel covalent deubiquitinase Usp9x/Usp24 inhibitor (IC50=1.6 uM).
EOAI3402143 shows increased aqueous solubility and greater cellular Usp9x inhibitory activity than WP1130.
EOAI3402143 displays nM apoptotic activity against other myeloma cell lines and diffuse large B-cell lymphomas cells.
EOAI3402143 increases tumor cell apoptosis, and fully blocks or regresses myeloma tumors in mice; also inhibis Usp5.
| M.Wt | 503.424 | |
| Formula | C25H28Cl2N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(E)-2-cyano-3-(3,6-dichloropyridin-2-yl)-N-(1-(4-(2-morpholinoethoxy)phenyl)butyl)acrylamide |
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1. Peterson LF, et al. Blood. 2015 Jun 4;125(23):3588-97.
2. Potu H, et al. Oncotarget. 2014 Jul 30;5(14):5559-69.
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