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Chemical Structure : Edasalonexent
Catalog No.: PC-35289Not For Human Use, Lab Use Only.
Edasalonexent (CAT-1004) is a bifunctional, orally administered small molecule that covalently links 2 compounds known to inhibit NF‐κB, salicylic acid and docosahexaenoic acid (DHA).
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Edasalonexent (CAT-1004) is a bifunctional, orally administered small molecule that covalently links 2 compounds known to inhibit NF‐κB, salicylic acid and docosahexaenoic acid (DHA); significantly inhibits NF-κB p65-dependent inflammatory responses as well as downstream proinflammatory genes modulated by p65 in the golden retriever DMD model; Edasalonexent is hydrolyzed by FAAH to release salicylic acid and DHA intracellularly and to suppress activated NF-κB.
Other Indication
Phase 2 Clinical
| M.Wt | 490.688 | |
| Formula | C31H42N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Donovan JM, et al. J Clin Pharmacol. 2017 May;57(5):627-639.
2. Vu CB, et al. J Med Chem. 2016 Feb 11;59(3):1217-31.
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