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Chemical Structure : Elacestrant dihydrochloride
CAS No.: 1349723-93-8
Catalog No.: PC-45734Not For Human Use, Lab Use Only.
Elacestrant (RAD-1901) is a novel, orally bioavailable small-molecule selective estrogen receptor degrader (SERD).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $280 | In stock | |
| 10 mg | $400 | In stock | |
| 50 mg | $1200 | In stock | |
| 100 mg | $1680 | In stock |
Bulk size, bulk discount!
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Elacestrant (RAD-1901) is a novel, orally bioavailable small-molecule selective estrogen receptor degrader (SERD); inhibits ERα expression in MCF-7 cells (IC50=0.6 nM); induces the degradation of ER, inhibits ER-mediated signaling and growth of ER+ breast cancer cell lines in vitro and in vivo, and significantly inhibits tumor growth of multiple PDX models.
Breast Cancer
Phase 2 Clinical
| M.Wt | 531.5568 | |
| Formula | C30H40Cl2N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 17.6 mg/mL; H2O |
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| Chemical Name/SMILES |
2-Naphthalenol, 6-[2-[ethyl[[4-[2-(ethylamino)ethyl]phenyl]methyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydro-, hydrochloride (1:2), (6R)- |
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1. Wardell SE, et al. Endocr Relat Cancer. 2015 Oct;22(5):713-24.
2. Garner F, et al. Anticancer Drugs. 2015 Oct;26(9):948-56.
3. Bihani T, et al. Clin Cancer Res. 2017 May 4. pii: clincanres.2561.2016.
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